Watch Man Utd V Reading Live Stream Online FA Cup 18/2/2013, Live Streaming Man Utd V Reading FA Cup Video Free
Adam Le Fondre and Noel Hunt are in contention while Jason Roberts (hip) and Alex McCarthy (shoulder) are out.
Manchester's United Paul Scholes is out for another two weeks with a knee injury, so Tom Cleverley and Anderson could both be included.
Other changes could include returns for Javier Hernandez, Nani and Ashley Young following the draw with Real Madrid.
Last time these two teams played each other in the Premier League in December, United won a thrilling game 4-3 at the Madejski with all the goals coming in the first half.
"In many people's eyes Monday would be, 'yes, it's Reading, we have just been to Madrid, it was a great night, Monday will take care of itself'," the Manchester United boss said.
"Monday can't take care of itself. We have to take care of that.
"We must get a performance off the players that respects our opponents and also the fact the FA Cup can produce shocks."
The Scot added: "Reading are a team who are showing plenty of fighting qualities, as you would expect given they are down near the bottom [of the Premier League].
"I will make some changes but I don't think the incentive to get to the quarter-final is lost on any of the players.
"There is a good spirit and they're all contributing. Whatever side I pick we're expected to qualify."